At St James’ Park, Newcastle faced injury challenges, forcing Eddie Howe to include three goalkeepers on the substitutes’ bench.
Despite this, sixth-placed Newcastle overcame recent defeats, with Alexander Isak scoring in the 13th minute from Lewis Miley’s pass.
Raheem Sterling’s impressive free-kick equalized for Chelsea ten minutes later, but Jamaal Lascelles headed in to regain Newcastle’s lead in the 60th minute. Shortly after, Joelinton capitalized on Thiago Silva’s mistake to extend the lead.
Chelsea’s Reece James received a second booking in the 73rd minute, leading to his dismissal.
Newcastle sealed the victory when Anthony Gordon scored 10 minutes later, marking the heaviest defeat of Pochettino’s first season in charge.
Elsewhere, Luton secured their first home league win, defeating Crystal Palace 2-1 with Jacob Brown’s 83rd-minute goal.
West Ham staged a comeback, winning 2-1 against Burnley, while Brighton triumphed 3-2 at Nottingham Forest, inspired by Joao Pedro. Bournemouth won 3-1 at Sheffield United, with Marcus Tavernier scoring twice.